Letairis 5 mg/1

Letairis Tablet, film coated is a product of Gilead Sciences

Group: Approved Antihypertensives for Pulmonary Arterial Hypertension

Name: Letairis

Dosage: Tablet, film coated

Strength: 5 mg/1

Route: Oral

Pharmaceutical company : Gilead Sciences

You can also find other alternative products such as : Volibris (5 mg) from Glaxo Group Limited Letairis (10 mg/1) from Gilead Sciences Volibris (5 mg) from Glaxo Group Limited Volibris (5 mg) from Glaxo Group Limited Volibris (5 mg) from Glaxo Group Limited Volibris (5 mg) from Glaxosmithkline Inc Letairis (5 mg/1) from Gilead Sciences Letairis (10 mg/1) from Gilead Sciences

Indication: Ambrisentan is indicated for treatment of idiopathic (‘primary’) pulmonary arterial hypertension (IPAH) and pulmonary arterial hypertension (PAH) associated with connective tissue disease in patients with WHO functional class II or III symptoms. In the United States of America, ambrisentan is also indicated in combination with tadalafil to reduce the risks of disease progression and hospitalization for worsening PAH, and to improve exercise ability.

Category:

  • Acids, Carbocyclic
  • Antihypertensive Agents
  • Antihypertensives for Pulmonary Arterial Hypertension
  • Cytochrome P-450 CYP3A Substrates
  • Cytochrome P-450 CYP3A4 Substrates
  • Cytochrome P-450 CYP3A5 Substrates
  • Endothelin Receptor Antagonists
  • Hypertension, Pulmonary
  • OATP1B1/SLCO1B1 Substrates
  • P-glycoprotein/ABCB1 Substrates
  • Vasodilating Agents
  • Food Interactions; No interactions found.

    Ambrisentan Definition:
    Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. In addition, it is approved in the United States for use in combination with tadalafil to reduce the risks of disease progression, hospitalization and to improve exercise ability. Studies establishing the efficacy of Ambrisentan included patients with both idiopathic or heritable pulmonary arterial hypertension and those with pulmonary arterial hypertension associated with connective tissue diseases. Patients studied displayed symptoms and etiologies predominantly of WHO Functional Class II-III. As an endothelin receptor antagonist, Ambrisentan prevents endogenous endothelin peptide from constricting the muscles in blood vessels, allowing them to relax and permit a reduction in blood pressure.

    More Letairis 5 mg/1

    LETAIRIS Rx

    Therapeutic indications Pulmonary hypertension


    Moderate to severe hepatic impairment: not recommended..Indications for LETAIRIS: Pulmonary arterial hypertension (PAH) (WHO Group I) in patients with WHO Class II or III symptoms to improve exercise ability and delay clinical worsening, or in combination with tadalafil to reduce the risks of disease progression and hospitalization for worsening PAH, and to improve exercise ability.. Pharmacological Class: Endothelin receptor antagonist..


    LETAIRIS Rx

    Therapeutic indications Pulmonary hypertension


    Moderate to severe hepatic impairment: not recommended.. Adverse Reactions: Peripheral edema, nasal congestion, sinusitis, flushing, elevated liver enzymes; decreased sperm counts, hematologic changes; in combination with tadalafil: also headache, cough, anemia, dyspepsia, bronchitis..letairisrems..


    Letairis

    Therapeutic indications Ambrisentan is used to treat high blood pressure in the lungs (pulmonary arterial hypertension)

    A very serious allergic reaction to this drug is rare.. You may report side effects to Health Canada at 1-866-234-2345..In the US -Call your doctor for medical advice about side effects..
    Women who may become pregnant must have a negative pregnancy test before starting this medication, once a month while taking it, and for 1 month after stopping the medication.. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.. Birth control should still be used, even if your partner had a vasectomy..


    Effects of Letairis 5 mg/1 by reaction with another drug or drugs

  • The metabolism of Mexiletine can be decreased when combined with Ambrisentan.
  • The serum concentration of Ambrisentan can be increased when it is combined with Acetaminophen.
  • The metabolism of Ambrisentan can be increased when combined with Phenobarbital.
  • Tranylcypromine may increase the hypotensive activities of Ambrisentan.
  • The metabolism of Ambrisentan can be decreased when combined with Zafirlukast.
  • The metabolism of Tadalafil can be decreased when combined with Ambrisentan.
  • The metabolism of Ambrisentan can be decreased when combined with Paricalcitol.
  • The metabolism of Ambrisentan can be decreased when combined with Zafirlukast.
  • The serum concentration of Ambrisentan can be decreased when it is combined with St. John's Wort.
  • The metabolism of Pregabalin can be decreased when combined with Ambrisentan.
  • The serum concentration of Ambrisentan can be increased when it is combined with Tetrandrine.
  • The metabolism of Ambrisentan can be increased when combined with Mitotane.
  • The metabolism of Ambrisentan can be decreased when combined with Cobicistat.
  • The metabolism of Mometasone can be decreased when combined with Ambrisentan.
  • The metabolism of Ambrisentan can be decreased when combined with Nicardipine.
  • The serum concentration of Ambrisentan can be increased when it is combined with Etoposide.
  • The metabolism of Ambrisentan can be decreased when combined with Galantamine.
  • Ticrynafen may increase the hypotensive activities of Ambrisentan.
  • The therapeutic efficacy of Ambrisentan can be decreased when used in combination with Indomethacin.
  • The serum concentration of Ambrisentan can be increased when it is combined with Sapropterin.